Assay Detail
Binding
CHEMBL1104433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by FLIPR assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.03 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092678 | — | — | 1 | 5.52 |
| CHEMBL1092748 | — | — | 1 | 5.40 |
| CHEMBL1092941 | — | — | 1 | 4.66 |
| CHEMBL1091605 | — | — | 1 | 4.52 |
| CHEMBL1093318 | — | — | 1 | - |
| CHEMBL1090893 | — | — | 1 | - |
| CHEMBL1092940 | — | — | 1 | - |
| CHEMBL1091604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092678 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1092748 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1092941 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1091605 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1093318 | — | IC50 | - | — | - | |
| CHEMBL1090893 | — | IC50 | - | — | - | |
| CHEMBL1092940 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1091604 | — | IC50 | > | 80000.0 | nM | - |