Assay Detail
Binding
CHEMBL1104444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of squalene synthase in rat liver microsomes assessed as conversion of [1-3H]FPP to [3H]squalene level after 60 mins by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 6.19 |
| CHEMBL1091856 | — | — | 1 | 5.43 |
| CHEMBL1091027 | — | — | 1 | 5.10 |
| CHEMBL1090779 | — | — | 1 | 4.75 |
| CHEMBL1093434 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1091856 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL1091027 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL1090779 | — | IC50 | = | 17680.0 | nM | 4.75 |
| CHEMBL1093434 | — | IC50 | = | 22950.0 | nM | 4.64 |