Assay Detail
Functional
CHEMBL1104486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania amazonensis MHOM/BR/76/LTB-012 amastigotes infected BALB/c mouse macrophages after 48 hrs by MTT assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.05 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.00 |
| CHEMBL1090250 | — | — | 1 | 6.30 |
| CHEMBL1090597 | — | — | 1 | 6.05 |
| CHEMBL1091956 | — | — | 1 | 5.92 |
| CHEMBL1091972 | — | — | 1 | 5.89 |
| CHEMBL1092685 | — | — | 1 | 5.77 |
| CHEMBL1090595 | — | — | 1 | 5.77 |
| CHEMBL1092279 | — | — | 1 | 5.70 |
| CHEMBL1090596 | — | — | 1 | 5.66 |
| CHEMBL1090594 | — | — | 1 | 5.48 |
| CHEMBL1092684 | — | — | 1 | 5.44 |
| CHEMBL1093905 | — | — | 1 | 5.38 |
| CHEMBL1093872 | — | — | 1 | 5.28 |
| CHEMBL1090591 | — | — | 1 | 5.14 |
| CHEMBL1089322 | — | — | 1 | 5.14 |
| CHEMBL1091957 | — | — | 1 | 5.01 |
| CHEMBL1092261 | — | — | 1 | 5.00 |
| CHEMBL1093245 | — | — | 1 | 4.90 |
| CHEMBL1093995 | — | — | 1 | 4.80 |
| CHEMBL1090564 | — | — | 1 | 4.78 |
| CHEMBL1090368 | — | — | 1 | 4.72 |
| CHEMBL1093852 | — | — | 1 | 4.54 |
| CHEMBL1090899 | — | — | 1 | 4.53 |
| CHEMBL1091973 | — | — | 1 | 4.49 |
| CHEMBL1090900 | — | — | 1 | 4.48 |
| CHEMBL1090898 | — | — | 1 | 4.44 |
| CHEMBL1090251 | — | — | 1 | 4.42 |
| CHEMBL1093506 | — | — | 1 | 4.41 |
| CHEMBL1093851 | — | — | 1 | 4.39 |
| CHEMBL1090592 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1090250 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1090597 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1091956 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1091972 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1092685 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1090595 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1092279 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1090596 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1090594 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1092684 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1093905 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1093872 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1090591 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1089322 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1091957 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1092261 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1093245 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1093995 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1090564 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL1090368 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1093852 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL1090899 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL1091973 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL1090900 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL1090898 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL1090251 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL1093506 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1090592 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL1093851 | — | IC50 | = | 40600.0 | nM | 4.39 |
| CHEMBL1092698 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL1090565 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL1093232 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL1092699 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL1093231 | — | IC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL1093850 | — | IC50 | = | 112600.0 | nM | - |
| CHEMBL1090252 | — | IC50 | = | 107800.0 | nM | - |
| CHEMBL1092262 | — | IC50 | = | 232600.0 | nM | - |
| CHEMBL1091230 | — | IC50 | = | 182300.0 | nM | - |