Assay Detail
Binding
CHEMBL1104618
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Inhibition of ATR by DELFIA assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.88 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563985 | — | — | 1 | 5.32 |
| CHEMBL1095932 | — | — | 1 | 5.11 |
| CHEMBL1095627 | — | — | 1 | 4.94 |
| CHEMBL1095933 | — | — | 1 | 4.93 |
| CHEMBL562999 | — | — | 1 | 4.58 |
| CHEMBL561907 | — | — | 1 | 4.38 |
| CHEMBL1095626 | — | — | 1 | - |
| CHEMBL1094981 | — | — | 1 | - |
| CHEMBL1098242 | — | — | 1 | - |
| CHEMBL1097942 | — | — | 1 | - |
| CHEMBL1098243 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563985 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1095932 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1095627 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1095933 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL562999 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL561907 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL1095626 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1094981 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1098242 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1097942 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1098243 | — | IC50 | > | 50000.0 | nM | - |