Assay Detail
Functional
CHEMBL1104833
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Inhibition of HSV1 KOS DNA polymerase infected in african green monkey Vero cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097364 | — | — | 1 | 6.92 |
| CHEMBL1095087 | — | — | 1 | 6.44 |
| CHEMBL1095387 | — | — | 1 | 6.43 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.36 |
| CHEMBL1096390 | — | — | 1 | 6.12 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097364 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1095087 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1095387 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL1096390 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 3300.0 | nM | 5.48 |