Assay Detail
Binding
CHEMBL1104835
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Inhibition of VZV KOS DNA polymerase infected in HFF cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HFF |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.42 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097364 | — | — | 1 | 7.16 |
| CHEMBL1095087 | — | — | 1 | 6.72 |
| CHEMBL1096390 | — | — | 1 | 6.64 |
| CHEMBL1095387 | — | — | 1 | 6.42 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.33 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097364 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1095087 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1096390 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1095387 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 5800.0 | nM | 5.24 |