Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1104895

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HIV1 gp120 binding to CD4 in human HeLa cells by cell fusion assay
ChEMBL ↗
104
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Cell Type HeLa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

CoMFA and CoMSIA studies on HIV-1 attachment inhibitors.
Lu P, Wei X, Zhang R.
Eur J Med Chem (2010) 45 : 1792 -1798
PubMed 20149491 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 104 7.57 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL523362 — — 2 10.22
CHEMBL522345 — — 2 10.22
CHEMBL492586 — — 2 10.15
CHEMBL494002 — — 2 9.89
CHEMBL522022 — — 2 9.89
CHEMBL494547 — — 2 9.85
CHEMBL522322 — — 2 9.64
CHEMBL494225 — — 2 9.46
CHEMBL495019 — — 2 9.38
CHEMBL493738 — — 2 9.35
CHEMBL445522 — — 2 9.30
CHEMBL523864 — — 2 9.28
CHEMBL522175 — — 2 9.25
CHEMBL523717 — — 2 9.15
CHEMBL493000 — — 2 8.77
CHEMBL495004 — — 2 8.72
CHEMBL135339 — — 2 8.59
CHEMBL523842 — — 2 8.37
CHEMBL522687 — — 2 8.36
CHEMBL492937 — — 2 8.35
CHEMBL494358 — — 2 8.31
CHEMBL523372 — — 2 8.18
CHEMBL522372 — — 2 8.14
CHEMBL524048 — — 2 8.09
CHEMBL495031 — — 2 7.76
CHEMBL524010 — — 2 7.68
CHEMBL494164 — — 2 7.64
CHEMBL494349 — — 2 7.62
CHEMBL493838 — — 2 7.37
CHEMBL523369 — — 2 7.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL523362 — EC50 = 0.06026 nM 10.22
CHEMBL522345 — EC50 = 0.06026 nM 10.22
CHEMBL523362 — EC50 = 0.06 nM 10.22
CHEMBL522345 — EC50 = 0.06 nM 10.22
CHEMBL492586 — EC50 = 0.07079 nM 10.15
CHEMBL492586 — EC50 = 0.07 nM 10.15
CHEMBL494002 — EC50 = 0.1288 nM 9.89
CHEMBL522022 — EC50 = 0.1288 nM 9.89
CHEMBL494002 — EC50 = 0.13 nM 9.89
CHEMBL522022 — EC50 = 0.13 nM 9.89
CHEMBL494547 — EC50 = 0.1413 nM 9.85
CHEMBL494547 — EC50 = 0.14 nM 9.85
CHEMBL522322 — EC50 = 0.2291 nM 9.64
CHEMBL522322 — EC50 = 0.23 nM 9.64
CHEMBL494225 — EC50 = 0.3467 nM 9.46
CHEMBL494225 — EC50 = 0.35 nM 9.46
CHEMBL495019 — EC50 = 0.4169 nM 9.38
CHEMBL495019 — EC50 = 0.42 nM 9.38
CHEMBL493738 — EC50 = 0.45 nM 9.35
CHEMBL493738 — EC50 = 0.4467 nM 9.35
CHEMBL445522 — EC50 = 0.5012 nM 9.30
CHEMBL445522 — EC50 = 0.5 nM 9.30
CHEMBL523864 — EC50 = 0.52 nM 9.28
CHEMBL523864 — EC50 = 0.5248 nM 9.28
CHEMBL522175 — EC50 = 0.56 nM 9.25
CHEMBL522175 — EC50 = 0.5623 nM 9.25
CHEMBL523717 — EC50 = 0.7079 nM 9.15
CHEMBL523717 — EC50 = 0.71 nM 9.15
CHEMBL493000 — EC50 = 1.698 nM 8.77
CHEMBL493000 — EC50 = 1.7 nM 8.77
CHEMBL495004 — EC50 = 1.905 nM 8.72
CHEMBL495004 — EC50 = 1.9 nM 8.72
CHEMBL135339 — EC50 = 2.59 nM 8.59
CHEMBL135339 — EC50 = 2.57 nM 8.59
CHEMBL523842 — EC50 = 4.3 nM 8.37
CHEMBL523842 — EC50 = 4.266 nM 8.37
CHEMBL522687 — EC50 = 4.365 nM 8.36
CHEMBL522687 — EC50 = 4.4 nM 8.36
CHEMBL492937 — EC50 = 4.467 nM 8.35
CHEMBL492937 — EC50 = 4.5 nM 8.35
CHEMBL494358 — EC50 = 4.898 nM 8.31
CHEMBL494358 — EC50 = 4.9 nM 8.31
CHEMBL523372 — EC50 = 6.607 nM 8.18
CHEMBL523372 — EC50 = 6.6 nM 8.18
CHEMBL522372 — EC50 = 7.244 nM 8.14
CHEMBL522372 — EC50 = 7.3 nM 8.14
CHEMBL524048 — EC50 = 8.128 nM 8.09
CHEMBL524048 — EC50 = 8.2 nM 8.09
CHEMBL495031 — EC50 = 17.38 nM 7.76
CHEMBL495031 — EC50 = 17.4 nM 7.76