Assay Detail
Binding
CHEMBL1105109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA addition measured after 60 mins by HPLC based scintillation assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.39 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1087015 | — | — | 1 | 9.00 |
| CHEMBL1080909 | — | — | 1 | 8.52 |
| CHEMBL1081257 | — | — | 1 | 8.52 |
| CHEMBL1076688 | — | — | 1 | 8.40 |
| CHEMBL1087772 | — | — | 1 | 8.40 |
| CHEMBL1081111 | — | — | 1 | 8.10 |
| CHEMBL1081255 | — | — | 1 | 7.92 |
| CHEMBL1081996 | — | — | 1 | 7.85 |
| CHEMBL1087014 | — | — | 1 | 7.82 |
| CHEMBL1081997 | — | — | 1 | 7.47 |
| CHEMBL1081112 | — | — | 1 | 7.39 |
| CHEMBL1080559 | — | — | 1 | 7.12 |
| CHEMBL1081258 | — | — | 1 | 7.08 |
| CHEMBL576820 | — | — | 1 | 6.97 |
| CHEMBL1080941 | — | — | 1 | 6.90 |
| CHEMBL1081825 | — | — | 1 | 6.82 |
| CHEMBL1081113 | — | — | 1 | 6.79 |
| CHEMBL1076698 | — | — | 1 | 6.17 |
| CHEMBL1081826 | — | — | 1 | 6.12 |
| CHEMBL1081827 | — | — | 1 | 6.12 |
| CHEMBL1080940 | — | — | 1 | 5.79 |
| CHEMBL1081256 | — | — | 1 | - |
| CHEMBL1080558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1087015 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1080909 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1081257 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1076688 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1087772 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1081111 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1081255 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1081996 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1087014 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1081997 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1081112 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1080559 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1081258 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL576820 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1080941 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL1081825 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1081113 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1076698 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL1081826 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1081827 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1080940 | — | IC50 | = | 1634.0 | nM | 5.79 |
| CHEMBL1081256 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1080558 | — | IC50 | > | 3000.0 | nM | - |