Assay Detail

CHEMBL1105535

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Binding

Binding affinity to rat recombinant 5HT6 receptor

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 6 (CHEMBL3372) ↗

Open DB target context

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5-hydroxytryptamine receptor 6 (CHEMBL3372) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 6

CHEMBL3372

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 6

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 6 (CHEMBL3372) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM.
Eur J Med Chem (2010) 45 : 782 -789
PubMed 19939513 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.92	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL589390	LATREPIRDINE	3.0	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL589390	LATREPIRDINE	Ki	=	119.0	nM	6.92