Assay Detail
Binding
CHEMBL1105634
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Inhibition of human placental microsome CYP19
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117 | CHRYSIN | — | 1 | 9.00 |
| CHEMBL1098382 | — | — | 1 | 9.00 |
| CHEMBL224060 | VOROZOLE | 2.0 | 1 | 8.86 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 8.74 |
| CHEMBL1097371 | 11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B | — | 1 | 8.70 |
| CHEMBL294878 | — | — | 1 | 8.70 |
| CHEMBL516643 | — | — | 1 | 8.64 |
| CHEMBL9352 | NARINGENIN | — | 1 | 8.54 |
| CHEMBL29482 | — | — | 1 | 8.52 |
| CHEMBL389433 | LIAROZOLE | 2.0 | 1 | 8.30 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 8.30 |
| CHEMBL369471 | — | — | 1 | 8.22 |
| CHEMBL1094154 | — | — | 1 | 8.22 |
| CHEMBL1096439 | — | — | 1 | 8.16 |
| CHEMBL1099308 | 10-EPI-8-DEOXY-CUMAMBRIN B | — | 1 | 8.15 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 8.10 |
| CHEMBL300814 | FLAVANONE | — | 1 | 8.06 |
| CHEMBL1097980 | — | — | 1 | 8.06 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 7.99 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.96 |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 7.94 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 7.92 |
| CHEMBL1097041 | — | — | 1 | 7.89 |
| CHEMBL1094331 | — | — | 1 | 7.86 |
| CHEMBL1399 | ANASTROZOLE | 4.0 | 1 | 7.82 |
| CHEMBL441260 | DEHYDROLEUCODIN | — | 1 | 7.82 |
| CHEMBL1094149 | — | — | 1 | 7.76 |
| CHEMBL1097763 | — | — | 1 | 7.76 |
| CHEMBL1097042 | — | — | 1 | 7.70 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117 | CHRYSIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1098382 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL224060 | VOROZOLE | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1097371 | 11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL294878 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL516643 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL29482 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL389433 | LIAROZOLE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL369471 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1094154 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1096439 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1099308 | 10-EPI-8-DEOXY-CUMAMBRIN B | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL275638 | FLAVONE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL300814 | FLAVANONE | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1097980 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL131921 | BIOCHANIN | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1444 | LETROZOLE | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL50 | QUERCETIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1097041 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1094331 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL441260 | DEHYDROLEUCODIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1399 | ANASTROZOLE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1094149 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL1097763 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL1097042 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL1097043 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1095413 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1097764 | LUDARTIN | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL294361 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1094426 | — | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL223874 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1094427 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1094428 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1098737 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1098424 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1098425 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL300109 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL93828 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1098426 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9165 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1096744 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL214932 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 600.0 | nM | 6.22 |