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Assay Detail

CHEMBL1105665

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.
Yenjai C, Wanich S.
Bioorg Med Chem Lett (2010) 20 : 2821 -2823
PubMed 20362442 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.61 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098028 1 6.58
CHEMBL123 ELLIPTECINE 1 5.75
CHEMBL1087979 1 4.62
CHEMBL1088513 1 4.52
CHEMBL107131 DIMETHYLPINOCEMBRIN 1 4.40
CHEMBL1088111 1 4.37
CHEMBL1088256 1 4.25
CHEMBL483550 1 4.10
CHEMBL1098362 1 4.07
CHEMBL1098369 1 4.04
CHEMBL399910 PINOCEMBRIN 2.0 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098028 IC50 = 260.0 nM 6.58
CHEMBL123 ELLIPTECINE IC50 = 1790.0 nM 5.75
CHEMBL1087979 IC50 = 23910.0 nM 4.62
CHEMBL1088513 IC50 = 30370.0 nM 4.52
CHEMBL107131 DIMETHYLPINOCEMBRIN IC50 = 39850.0 nM 4.40
CHEMBL1088111 IC50 = 43150.0 nM 4.37
CHEMBL1088256 IC50 = 56790.0 nM 4.25
CHEMBL483550 IC50 = 78800.0 nM 4.10
CHEMBL1098362 IC50 = 84900.0 nM 4.07
CHEMBL1098369 IC50 = 92140.0 nM 4.04
CHEMBL399910 PINOCEMBRIN IC50 = 99160.0 nM 4.00