Assay Detail
Binding
CHEMBL1105755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by spectrophotometric analysis
15
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.73 | 5.32 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | — | 1 | 5.32 |
| CHEMBL383563 | — | — | 1 | 5.08 |
| CHEMBL1087324 | — | — | 2 | 4.82 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.79 |
| CHEMBL1087322 | — | — | 2 | 4.65 |
| CHEMBL371723 | — | — | 2 | 4.63 |
| CHEMBL1087448 | — | — | 2 | 4.54 |
| CHEMBL1087578 | — | — | 2 | 4.51 |
| CHEMBL1087323 | — | — | 2 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL383563 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1087324 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1087322 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL371723 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL1087448 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL1087578 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL1087323 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL371723 | — | Activity | - | — | - | |
| CHEMBL1087322 | — | Activity | - | — | - | |
| CHEMBL1087323 | — | Activity | - | — | - | |
| CHEMBL1087578 | — | Activity | - | — | - | |
| CHEMBL1087324 | — | Activity | - | — | - | |
| CHEMBL1087448 | — | Activity | - | — | - |