Assay Detail
Binding
CHEMBL1105756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burke plot analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.99 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | — | 1 | 5.54 |
| CHEMBL383563 | — | — | 1 | 5.41 |
| CHEMBL1087324 | — | — | 1 | 4.94 |
| CHEMBL371723 | — | — | 1 | 4.90 |
| CHEMBL1087322 | — | — | 1 | 4.88 |
| CHEMBL1087448 | — | — | 1 | 4.83 |
| CHEMBL1087578 | — | — | 1 | 4.78 |
| CHEMBL1087323 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL383563 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL1087324 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL371723 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL1087322 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL1087448 | — | Ki | = | 14900.0 | nM | 4.83 |
| CHEMBL1087578 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL1087323 | — | Ki | = | 25200.0 | nM | 4.60 |