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Assay Detail

CHEMBL1105796

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]T0901317 from LXRbeta ligand binding domain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Ullrich JW, Morris R, Bernotas RC, Travins JM, Jetter J, Unwalla R, Quinet E, Nambi P, Feingold I, Huselton C, Enroth C, Wilhelmsson A, Goos-Nilsson A, Wrobel J.
Bioorg Med Chem Lett (2010) 20 : 2903 -2907
PubMed 20382019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 8.08 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098401 1 8.82
CHEMBL1097158 1 8.77
CHEMBL1094741 1 8.74
CHEMBL1098403 1 8.62
CHEMBL1097160 1 8.59
CHEMBL1098850 1 8.49
CHEMBL1097159 1 8.48
CHEMBL1096719 1 8.42
CHEMBL1097799 1 8.39
CHEMBL1095714 1 8.36
CHEMBL1097140 1 8.31
CHEMBL1098832 1 8.28
CHEMBL62136 T091317 1 8.05
CHEMBL1098831 1 7.48
CHEMBL1098402 1 6.96
CHEMBL1094742 1 6.45
CHEMBL1099133 1 6.20
CHEMBL1095715 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098401 IC50 = 1.5 nM 8.82
CHEMBL1097158 IC50 = 1.7 nM 8.77
CHEMBL1094741 IC50 = 1.8 nM 8.74
CHEMBL1098403 IC50 = 2.4 nM 8.62
CHEMBL1097160 IC50 = 2.6 nM 8.59
CHEMBL1098850 IC50 = 3.2 nM 8.49
CHEMBL1097159 IC50 = 3.3 nM 8.48
CHEMBL1096719 IC50 = 3.8 nM 8.42
CHEMBL1097799 IC50 = 4.1 nM 8.39
CHEMBL1095714 IC50 = 4.4 nM 8.36
CHEMBL1097140 IC50 = 4.9 nM 8.31
CHEMBL1098832 IC50 = 5.2 nM 8.28
CHEMBL62136 T091317 IC50 = 9.0 nM 8.05
CHEMBL1098831 IC50 = 33.0 nM 7.48
CHEMBL1098402 IC50 = 109.0 nM 6.96
CHEMBL1094742 IC50 = 355.0 nM 6.45
CHEMBL1099133 IC50 = 629.0 nM 6.20
CHEMBL1095715 IC50 > 1000.0 nM -