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Assay Detail

CHEMBL1105798

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Huh-7
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Ullrich JW, Morris R, Bernotas RC, Travins JM, Jetter J, Unwalla R, Quinet E, Nambi P, Feingold I, Huselton C, Enroth C, Wilhelmsson A, Goos-Nilsson A, Wrobel J.
Bioorg Med Chem Lett (2010) 20 : 2903 -2907
PubMed 20382019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.55 7.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098403 1 7.12
CHEMBL1097799 1 7.04
CHEMBL1098401 1 7.00
CHEMBL1096719 1 6.97
CHEMBL1097158 1 6.79
CHEMBL62136 T091317 1 6.77
CHEMBL1098850 1 6.76
CHEMBL1097159 1 6.71
CHEMBL1094741 1 6.55
CHEMBL1097160 1 6.29
CHEMBL1095714 1 6.28
CHEMBL1097140 1 6.25
CHEMBL1098832 1 6.24
CHEMBL1098831 1 5.97
CHEMBL1098402 1 5.48
CHEMBL1099133 1 -
CHEMBL1094742 1 -
CHEMBL1095715 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098403 EC50 = 76.0 nM 7.12
CHEMBL1097799 EC50 = 91.0 nM 7.04
CHEMBL1098401 EC50 = 100.0 nM 7.00
CHEMBL1096719 EC50 = 106.0 nM 6.97
CHEMBL1097158 EC50 = 161.0 nM 6.79
CHEMBL62136 T091317 EC50 = 170.0 nM 6.77
CHEMBL1098850 EC50 = 175.0 nM 6.76
CHEMBL1097159 EC50 = 195.0 nM 6.71
CHEMBL1094741 EC50 = 284.0 nM 6.55
CHEMBL1097160 EC50 = 512.0 nM 6.29
CHEMBL1095714 EC50 = 525.0 nM 6.28
CHEMBL1097140 EC50 = 565.0 nM 6.25
CHEMBL1098832 EC50 = 580.0 nM 6.24
CHEMBL1098831 EC50 = 1080.0 nM 5.97
CHEMBL1098402 EC50 = 3300.0 nM 5.48
CHEMBL1099133 EC50 - -
CHEMBL1094742 EC50 - -
CHEMBL1095715 EC50 - -