Assay Detail
Binding
CHEMBL1105835
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Inhibition of telomerase in human A2780 cells by TRAP assay
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 6.28 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140180 | — | — | 1 | 7.75 |
| CHEMBL1078511 | — | — | 1 | 7.75 |
| CHEMBL139511 | — | — | 1 | 7.70 |
| CHEMBL336444 | — | — | 1 | 7.40 |
| CHEMBL138811 | — | — | 1 | 7.30 |
| CHEMBL141540 | — | — | 1 | 7.30 |
| CHEMBL335132 | — | — | 1 | 7.22 |
| CHEMBL336417 | — | — | 1 | 7.22 |
| CHEMBL343795 | — | — | 1 | 7.16 |
| CHEMBL335819 | — | — | 1 | 7.13 |
| CHEMBL337762 | — | — | 1 | 7.10 |
| CHEMBL182871 | — | — | 1 | 7.10 |
| CHEMBL138187 | — | — | 1 | 7.10 |
| CHEMBL139287 | — | — | 1 | 7.05 |
| CHEMBL184587 | — | — | 1 | 7.01 |
| CHEMBL138761 | — | — | 1 | 7.00 |
| CHEMBL141661 | — | — | 1 | 7.00 |
| CHEMBL336434 | — | — | 1 | 7.00 |
| CHEMBL138487 | — | — | 1 | 7.00 |
| CHEMBL343609 | — | — | 1 | 6.96 |
| CHEMBL335564 | — | — | 1 | 6.85 |
| CHEMBL137809 | — | — | 1 | 6.82 |
| CHEMBL138357 | — | — | 1 | 6.77 |
| CHEMBL345035 | — | — | 1 | 6.77 |
| CHEMBL361868 | — | — | 1 | 6.70 |
| CHEMBL186346 | — | — | 1 | 6.70 |
| CHEMBL3707105 | — | — | 1 | 6.70 |
| CHEMBL142036 | — | — | 1 | 6.70 |
| CHEMBL1078502 | — | — | 1 | 6.68 |
| CHEMBL342480 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140180 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1078511 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL139511 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL336444 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL138811 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL141540 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL335132 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL336417 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL343795 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL335819 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL337762 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL182871 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL138187 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL139287 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL184587 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL138761 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL138487 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL336434 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL141661 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL343609 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL335564 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL137809 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL138357 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL345035 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL142036 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL186346 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL361868 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3707105 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1078502 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL342480 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL137973 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1078222 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL140084 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL181970 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL186019 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL141740 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL341985 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL137928 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL186971 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL139443 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL186933 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL343041 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL139500 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL138369 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL140354 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL309919 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL186848 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL365070 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL184711 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL186489 | — | IC50 | = | 1900.0 | nM | 5.72 |