Assay Detail

CHEMBL1106164

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Functional

Inhibition of capsaicin-induced vasodilation in orally dosed rhesus monkey

ChEMBL ↗

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Target

Rhesus monkey (CHEMBL614875) ↗

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Rhesus monkey (CHEMBL614875) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rhesus monkey

CHEMBL614875

Anchored from Assay target.

Protein identity Rhesus monkey

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Macaca mulatta
Confidence	1 — Organism
Curated By	Autocuration

Target

Rhesus monkey (CHEMBL614875) ↗

Type	ORGANISM
Organism	Macaca mulatta

Publication

Identification of potent, highly constrained CGRP receptor antagonists.

Stump CA, Bell IM, Bednar RA, Fay JF, Gallicchio SN, Hershey JC, Jelley R, Kreatsoulas C, Moore EL, Mosser SD, Quigley AG, Roller SA, Salvatore CA, Sharik SS, Theberge CR, Zartman CB, Kane SA, Graham SL, Selnick HG, Vacca JP, Williams TM.
Bioorg Med Chem Lett (2010) 20 : 2572 -2576
PubMed 20299218 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.26	5.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1092838	—	—	1	5.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1092838	—	EC50	=	5500.0	nM	5.26