Assay Detail
Binding
CHEMBL1106332
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Inhibition of Brucella suis recombinant (6X)His tagged-beta carbonic anhydrase expressed in Escherichia coli BL21(DE3) after 15 mins by stopped flow carbon dioxide hydrase assay method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Brucella suis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089967 | — | — | 1 | 8.05 |
| CHEMBL1090523 | — | — | 1 | 8.04 |
| CHEMBL1093178 | — | — | 1 | 7.72 |
| CHEMBL1090524 | — | — | 1 | 7.55 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL1089637 | — | — | 1 | 7.19 |
| CHEMBL1092670 | — | — | 1 | 7.17 |
| CHEMBL1090522 | — | — | 1 | 6.99 |
| CHEMBL1089968 | — | — | 1 | 6.96 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089967 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1090523 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1093178 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1090524 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1089637 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1092670 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL1090522 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL1089968 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 2500.0 | nM | 5.60 |