Assay Detail
Binding
CHEMBL1106334
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Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093178 | — | — | 1 | 8.00 |
| CHEMBL1089637 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL1090524 | — | — | 1 | 7.85 |
| CHEMBL1092670 | — | — | 1 | 7.82 |
| CHEMBL1089967 | — | — | 1 | 7.80 |
| CHEMBL1090522 | — | — | 1 | 7.75 |
| CHEMBL1089968 | — | — | 1 | 7.64 |
| CHEMBL1090523 | — | — | 1 | 7.60 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093178 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1089637 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1090524 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1092670 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1089967 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1090522 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1089968 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1090523 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 240.0 | nM | 6.62 |