Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1106339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitumor activity against human MOLT4 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLT-4
Confidence 1 — Organism
Curated By Autocuration

Target

MOLT-4 (CHEMBL614177)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives.
Kraljević TG, Kristafor S, Suman L, Kralj M, Ametamey SM, Cetina M, Raić-Malić S.
Bioorg Med Chem (2010) 18 : 2704 -2712
PubMed 20211564 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.77 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185 FLUOROURACIL 4.0 1 7.52
CHEMBL803 CYTARABINE 4.0 1 6.00
CHEMBL1090872 1 5.30
CHEMBL1091192 1 5.30
CHEMBL1091194 1 4.72
CHEMBL1090656 1 -
CHEMBL1090546 1 -
CHEMBL1090551 1 -
CHEMBL1090871 1 -
CHEMBL1090657 1 -
CHEMBL1090873 1 -
CHEMBL1090874 1 -
CHEMBL1090525 1 -
CHEMBL1090850 1 -
CHEMBL1091722 1 -
CHEMBL1091193 1 -
CHEMBL1091195 1 -
CHEMBL1090849 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185 FLUOROURACIL IC50 = 30.0 nM 7.52
CHEMBL803 CYTARABINE IC50 = 1000.0 nM 6.00
CHEMBL1090872 IC50 = 5000.0 nM 5.30
CHEMBL1091192 IC50 = 5000.0 nM 5.30
CHEMBL1091194 IC50 = 19000.0 nM 4.72
CHEMBL1090656 IC50 > 100000.0 nM -
CHEMBL1090546 IC50 > 100000.0 nM -
CHEMBL1090551 IC50 > 100000.0 nM -
CHEMBL1090871 IC50 - -
CHEMBL1090657 IC50 - -
CHEMBL1090873 IC50 - -
CHEMBL1090874 IC50 - -
CHEMBL1090525 IC50 > 100000.0 nM -
CHEMBL1090850 IC50 > 100000.0 nM -
CHEMBL1091722 IC50 > 100000.0 nM -
CHEMBL1091193 IC50 > 100000.0 nM -
CHEMBL1091195 IC50 > 100000.0 nM -
CHEMBL1090849 IC50 - -