Assay Detail
Binding
CHEMBL1106345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]TZDM from amyloid beta (1 to 40) aggregates after 2 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for beta-amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.03 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092056 | — | — | 1 | 9.51 |
| CHEMBL1090843 | — | — | 1 | 9.24 |
| CHEMBL1090844 | — | — | 1 | 9.22 |
| CHEMBL1091188 | — | — | 1 | 9.21 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 9.11 |
| CHEMBL1090845 | — | — | 1 | 8.89 |
| CHEMBL55380 | — | — | 1 | 8.66 |
| CHEMBL1089499 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092056 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1090843 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL1090844 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1091188 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL1090845 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL55380 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1089499 | — | Ki | = | 3.94 | nM | 8.40 |