Assay Detail
Binding
CHEMBL1106346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates after 2 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for beta-amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.04 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091188 | — | — | 1 | 9.96 |
| CHEMBL1090845 | — | — | 1 | 9.68 |
| CHEMBL1092056 | — | — | 1 | 9.60 |
| CHEMBL1090843 | — | — | 1 | 9.22 |
| CHEMBL55380 | — | — | 1 | 9.05 |
| CHEMBL1090844 | — | — | 1 | 8.68 |
| CHEMBL1089499 | — | — | 1 | 8.33 |
| CHEMBL78012 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091188 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL1090845 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL1092056 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL1090843 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL55380 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1090844 | — | Ki | = | 2.09 | nM | 8.68 |
| CHEMBL1089499 | — | Ki | = | 4.64 | nM | 8.33 |
| CHEMBL78012 | — | Ki | = | 15.0 | nM | 7.82 |