Assay Detail
Binding
CHEMBL1106508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.99 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095121 | — | — | 1 | 10.15 |
| CHEMBL1095406 | — | — | 1 | 10.05 |
| CHEMBL1098752 | — | — | 1 | 9.85 |
| CHEMBL1099069 | — | — | 1 | 9.82 |
| CHEMBL1098055 | — | — | 1 | 9.52 |
| CHEMBL1098751 | — | — | 1 | 9.46 |
| CHEMBL1094399 | — | — | 1 | 9.40 |
| CHEMBL1097717 | — | — | 1 | 9.19 |
| CHEMBL1097718 | — | — | 1 | 9.11 |
| CHEMBL1098056 | — | — | 1 | 9.07 |
| CHEMBL1095122 | — | — | 1 | 9.03 |
| CHEMBL1097719 | — | — | 1 | 9.00 |
| CHEMBL1095176 | — | — | 1 | 8.73 |
| CHEMBL1098654 | — | — | 1 | 8.73 |
| CHEMBL1095455 | — | — | 1 | 8.53 |
| CHEMBL1095440 | — | — | 1 | 8.50 |
| CHEMBL1095405 | — | — | 1 | 8.48 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.46 |
| CHEMBL1095123 | — | — | 1 | 8.41 |
| CHEMBL1095760 | — | — | 1 | 8.19 |
| CHEMBL1097983 | — | — | 1 | 8.02 |
| CHEMBL1094098 | — | — | 1 | 8.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095121 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1095406 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1098752 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL1099069 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL1098055 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1098751 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1094399 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1097717 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL1097718 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL1098056 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL1095122 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL1097719 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL1095176 | — | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL1098654 | — | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL1095455 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL1095440 | — | IC50 | = | 3.15 | nM | 8.50 |
| CHEMBL1095405 | — | IC50 | = | 3.28 | nM | 8.48 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1095123 | — | IC50 | = | 3.92 | nM | 8.41 |
| CHEMBL1095760 | — | IC50 | = | 6.48 | nM | 8.19 |
| CHEMBL1097983 | — | IC50 | = | 9.52 | nM | 8.02 |
| CHEMBL1094098 | — | IC50 | = | 9.79 | nM | 8.01 |