Assay Detail
Binding
CHEMBL1106526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 9.38 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098465 | — | — | 1 | 10.96 |
| CHEMBL1094365 | — | — | 1 | 10.40 |
| CHEMBL1094249 | — | — | 1 | 10.30 |
| CHEMBL1094544 | — | — | 1 | 10.15 |
| CHEMBL1097506 | — | — | 1 | 10.15 |
| CHEMBL1098466 | — | — | 1 | 10.15 |
| CHEMBL1098141 | — | — | 1 | 10.10 |
| CHEMBL1097823 | — | — | 1 | 10.10 |
| CHEMBL1094191 | — | — | 1 | 10.06 |
| CHEMBL1097822 | — | — | 1 | 9.72 |
| CHEMBL1094499 | — | — | 1 | 9.70 |
| CHEMBL1094833 | — | — | 1 | 9.46 |
| CHEMBL1095186 | — | — | 1 | 9.42 |
| CHEMBL1094399 | — | — | 1 | 9.40 |
| CHEMBL1094830 | — | — | 1 | 9.38 |
| CHEMBL1094238 | — | — | 1 | 9.30 |
| CHEMBL1095175 | — | — | 1 | 9.19 |
| CHEMBL1095176 | — | — | 1 | 9.18 |
| CHEMBL1098114 | — | — | 1 | 9.14 |
| CHEMBL1097782 | — | — | 1 | 9.12 |
| CHEMBL1094832 | — | — | 1 | 9.11 |
| CHEMBL1094211 | — | — | 1 | 9.05 |
| CHEMBL1094490 | — | — | 1 | 8.92 |
| CHEMBL1097781 | — | — | 1 | 8.92 |
| CHEMBL1095185 | — | — | 1 | 8.85 |
| CHEMBL1094190 | — | — | 1 | 8.70 |
| CHEMBL1094500 | — | — | 1 | 8.64 |
| CHEMBL1097783 | — | — | 1 | 8.64 |
| CHEMBL1097780 | — | — | 1 | 8.60 |
| CHEMBL1094210 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098465 | — | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL1094365 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1094249 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1094544 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1097506 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1098466 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1098141 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1097823 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1094191 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL1097822 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL1094499 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1094833 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1095186 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1094399 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1094830 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1094238 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1095175 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL1095176 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL1098114 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL1097782 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL1094832 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL1094211 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL1094490 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1097781 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1095185 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1094190 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1094500 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1097783 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1097780 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1094210 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1096785 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1094517 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1094489 | — | IC50 | = | 0.007 | nM | - |