Assay Detail
Binding
CHEMBL1106530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by patch clamp electrophysiology
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094365 | — | — | 1 | 5.96 |
| CHEMBL1097783 | — | — | 1 | 5.55 |
| CHEMBL1094211 | — | — | 1 | - |
| CHEMBL1094832 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094365 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1097783 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1094211 | — | IC50 | - | — | - | |
| CHEMBL1094832 | — | IC50 | - | — | - |