Assay Detail
Binding
CHEMBL1106592
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Inhibition of PIM1
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81714 | — | — | 1 | 6.70 |
| CHEMBL39958 | — | — | 1 | 6.40 |
| CHEMBL37139 | — | — | 1 | 6.30 |
| CHEMBL36586 | — | — | 1 | 6.30 |
| CHEMBL81284 | — | — | 1 | 6.30 |
| CHEMBL83419 | — | — | 1 | 6.22 |
| CHEMBL418613 | — | — | 1 | 6.16 |
| CHEMBL82029 | — | — | 1 | 6.00 |
| CHEMBL83746 | — | — | 1 | 6.00 |
| CHEMBL39092 | — | — | 1 | 5.77 |
| CHEMBL40170 | — | — | 1 | 5.70 |
| CHEMBL309885 | — | — | 1 | 5.70 |
| CHEMBL81182 | — | — | 1 | 5.68 |
| CHEMBL39301 | — | — | 1 | 5.68 |
| CHEMBL37431 | — | — | 1 | 5.60 |
| CHEMBL1098529 | — | — | 1 | 5.55 |
| CHEMBL82633 | — | — | 1 | 5.55 |
| CHEMBL142246 | — | — | 1 | 5.52 |
| CHEMBL310321 | — | — | 1 | 5.52 |
| CHEMBL36640 | — | — | 1 | 5.51 |
| CHEMBL59548 | — | — | 1 | 5.51 |
| CHEMBL40148 | — | — | 1 | 5.50 |
| CHEMBL80008 | — | — | 1 | 5.48 |
| CHEMBL431508 | — | — | 1 | 5.47 |
| CHEMBL39883 | — | — | 1 | 5.40 |
| CHEMBL1096809 | — | — | 1 | 5.35 |
| CHEMBL341951 | — | — | 1 | 5.35 |
| CHEMBL1096159 | — | — | 1 | 5.30 |
| CHEMBL289303 | — | — | 1 | 5.30 |
| CHEMBL81686 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81714 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL39958 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL36586 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL81284 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL37139 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL83419 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL418613 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL82029 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL83746 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL39092 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL40170 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL309885 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL81182 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL39301 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL37431 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1098529 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL82633 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL142246 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL310321 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL36640 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL59548 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL40148 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL80008 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL431508 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL39883 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1096809 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL341951 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1096159 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL289303 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL81686 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL37869 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1098784 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1096158 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142412 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095744 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL58057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL39823 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096334 | — | IC50 | > | 10000.0 | nM | - |