Assay Detail
Binding
CHEMBL1106599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse DYRK1A expressed in Escherichia coli after 20 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL4750) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.62 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37139 | — | — | 1 | 5.89 |
| CHEMBL81714 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37139 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL81714 | — | IC50 | = | 4500.0 | nM | 5.35 |