Assay Detail
Binding
CHEMBL1106768
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Inhibition of COX2 in human whole blood
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.39 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224400 | — | — | 1 | 7.05 |
| CHEMBL147165 | — | — | 1 | 6.21 |
| CHEMBL224122 | — | — | 1 | 5.92 |
| CHEMBL148542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224400 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL147165 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL224122 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL148542 | — | IC50 | > | 100000.0 | nM | - |