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Assay Detail

CHEMBL1106839

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Lung
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL1075175)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.
Murata T, Sasaki K, Sato K, Yoshizaki F, Yamada H, Mutoh H, Umehara K, Miyase T, Warashina T, Aoshima H, Tabata H, Matsubara K.
J Nat Prod (2009) 72 : 1379 -1384
PubMed 19711986 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.02 5.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1080779 CLINOPODIC ACID C 1 5.49
CHEMBL518243 LITHOSPERMIC ACID 1 4.99
CHEMBL324842 ROSMARINIC ACID 1 4.57
CHEMBL1079357 CLINOPODIC ACID H 1 -
CHEMBL1079356 CLINOPODIC ACID F 1 -
CHEMBL1081512 CLINOPODIC ACID E 1 -
CHEMBL1080778 CLINOPODIC ACID B 1 -
CHEMBL1079231 CLINOPODIC ACID A 1 -
CHEMBL241405 METHYL ROSMARINATE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1080779 CLINOPODIC ACID C IC50 = 3260.0 nM 5.49
CHEMBL518243 LITHOSPERMIC ACID IC50 = 10200.0 nM 4.99
CHEMBL324842 ROSMARINIC ACID IC50 = 27200.0 nM 4.57
CHEMBL1079357 CLINOPODIC ACID H IC50 > 100000.0 nM -
CHEMBL1079356 CLINOPODIC ACID F IC50 > 100000.0 nM -
CHEMBL1081512 CLINOPODIC ACID E IC50 > 100000.0 nM -
CHEMBL1080778 CLINOPODIC ACID B IC50 > 100000.0 nM -
CHEMBL1079231 CLINOPODIC ACID A IC50 > 100000.0 nM -
CHEMBL241405 METHYL ROSMARINATE IC50 > 100000.0 nM -