Assay Detail
Functional
CHEMBL1106880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dog nicotinic acid receptor by [35S]GTPgammaS binding assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| EC50 | 1 | 8.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086657 | — | — | 1 | 8.89 |
| CHEMBL237248 | — | — | 1 | - |
| CHEMBL1086656 | — | — | 2 | - |
| CHEMBL1087302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086657 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL237248 | — | Activity | - | — | - | |
| CHEMBL1086656 | — | Activity | - | — | - | |
| CHEMBL1086656 | — | Activity | - | — | - | |
| CHEMBL1087302 | — | Activity | - | — | - |