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Assay Detail

CHEMBL1106909

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.
Kim KH, Choi SU, Lee KR.
Bioorg Med Chem Lett (2010) 20 : 1944 -1947
PubMed 20176479 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.12 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.80
CHEMBL1077309 1 5.36
CHEMBL1077310 1 5.25
CHEMBL1077307 1 5.03
CHEMBL269277 BETULINIC ACID 1.0 1 4.97
CHEMBL1077302 1 4.83
CHEMBL1077306 1 4.82
CHEMBL486986 POMOLIC ACID 1 4.76
CHEMBL1077308 1 4.68
CHEMBL383749 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 160.0 nM 6.80
CHEMBL1077309 IC50 = 4370.0 nM 5.36
CHEMBL1077310 IC50 = 5570.0 nM 5.25
CHEMBL1077307 IC50 = 9430.0 nM 5.03
CHEMBL269277 BETULINIC ACID IC50 = 10820.0 nM 4.97
CHEMBL1077302 IC50 = 14640.0 nM 4.83
CHEMBL1077306 IC50 = 15140.0 nM 4.82
CHEMBL486986 POMOLIC ACID IC50 = 17220.0 nM 4.76
CHEMBL1077308 IC50 = 20680.0 nM 4.68
CHEMBL383749 IC50 = 22100.0 nM 4.66