Assay Detail
Binding
CHEMBL1106928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human DHODH by using blue indicator dye DCIP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 8.52 |
| CHEMBL1084928 | — | — | 1 | 7.00 |
| CHEMBL1088743 | — | — | 1 | 6.30 |
| CHEMBL1088742 | — | — | 1 | 6.16 |
| CHEMBL1084927 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1084928 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1088743 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1088742 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1084927 | — | IC50 | = | 5500.0 | nM | 5.26 |