Assay Detail

CHEMBL1107040

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Functional

Cytotoxicity against human Caco-2 cells after 48 hrs by MTT assay

ChEMBL ↗

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Target

Caco-2 (CHEMBL614058) ↗

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Caco-2 (CHEMBL614058) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Caco-2

CHEMBL614058

Anchored from Assay target.

Protein identity Caco-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Caco-2
Confidence	1 — Organism
Curated By	Autocuration

Target

Caco-2 (CHEMBL614058) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae.

Carbone M, Irace C, Costagliola F, Castelluccio F, Villani G, Calado G, Padula V, Cimino G, Lucas Cervera J, Santamaria R, Gavagnin M.
Bioorg Med Chem Lett (2010) 20 : 2668 -2670
PubMed 20227875 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.25	8.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1092399	TAMBJAMINE K	—	1	8.46
CHEMBL1091177	—	—	1	4.04

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1092399	TAMBJAMINE K	IC50	=	3.5	nM	8.46
CHEMBL1091177	—	IC50	=	91000.0	nM	4.04