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Assay Detail

CHEMBL1107216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human coxsackievirus B2 Ohio-1 infected in african green monkey Vero cells after 3 days by plaque reduction assay
ChEMBL ↗
81
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Coxsackievirus B2 (strain Ohio-1)
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Coxsackievirus B2 (CHEMBL613202) ↗
Type ORGANISM
Organism Coxsackievirus B2

Publication

Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Tonelli M, Simone M, Tasso B, Novelli F, Boido V, Sparatore F, Paglietti G, Pricl S, Giliberti G, Blois S, Ibba C, Sanna G, Loddo R, La Colla P.
Bioorg Med Chem (2010) 18 : 2937 -2953
PubMed 20359898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 81 4.93 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1093512 — — 1 5.82
CHEMBL1091037 — — 1 5.60
CHEMBL1093508 — — 1 5.52
CHEMBL1093875 — — 1 5.52
CHEMBL1091652 — — 1 5.52
CHEMBL1093826 — — 1 5.40
CHEMBL1093920 — — 1 5.40
CHEMBL1091736 — — 1 5.30
CHEMBL1091257 — — 1 5.22
CHEMBL1092702 — — 1 5.16
CHEMBL1093919 — — 1 5.16
CHEMBL1093263 — — 1 5.05
CHEMBL1092978 — — 1 5.05
CHEMBL1093493 — — 1 5.05
CHEMBL1092701 — — 1 5.05
CHEMBL1092673 — — 1 5.00
CHEMBL1090936 — — 1 4.96
CHEMBL1092613 — — 1 4.96
CHEMBL1093553 — — 1 4.96
CHEMBL1092703 — — 1 4.96
CHEMBL1091258 — — 1 4.92
CHEMBL1090902 — — 1 4.89
CHEMBL1093906 — — 2 4.89
CHEMBL1092979 — — 1 4.89
CHEMBL1089234 — — 1 4.85
CHEMBL1091653 — — 1 4.80
CHEMBL1093988 — — 1 4.77
CHEMBL1092614 — — 1 4.77
CHEMBL1093874 — — 1 4.72
CHEMBL111951 — — 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1093512 — EC50 = 1500.0 nM 5.82
CHEMBL1091037 — EC50 = 2500.0 nM 5.60
CHEMBL1093875 — EC50 = 3000.0 nM 5.52
CHEMBL1091652 — EC50 = 3000.0 nM 5.52
CHEMBL1093508 — EC50 = 3000.0 nM 5.52
CHEMBL1093826 — EC50 = 4000.0 nM 5.40
CHEMBL1093920 — EC50 = 4000.0 nM 5.40
CHEMBL1091736 — EC50 = 5000.0 nM 5.30
CHEMBL1091257 — EC50 = 6000.0 nM 5.22
CHEMBL1092702 — EC50 = 7000.0 nM 5.16
CHEMBL1093919 — EC50 = 7000.0 nM 5.16
CHEMBL1093263 — EC50 = 9000.0 nM 5.05
CHEMBL1092978 — EC50 = 9000.0 nM 5.05
CHEMBL1092701 — EC50 = 9000.0 nM 5.05
CHEMBL1093493 — EC50 = 9000.0 nM 5.05
CHEMBL1092673 — EC50 = 10000.0 nM 5.00
CHEMBL1092703 — EC50 = 11000.0 nM 4.96
CHEMBL1090936 — EC50 = 11000.0 nM 4.96
CHEMBL1092613 — EC50 = 11000.0 nM 4.96
CHEMBL1093553 — EC50 = 11000.0 nM 4.96
CHEMBL1091258 — EC50 = 12000.0 nM 4.92
CHEMBL1090902 — EC50 = 13000.0 nM 4.89
CHEMBL1092979 — EC50 = 13000.0 nM 4.89
CHEMBL1093906 — EC50 = 13000.0 nM 4.89
CHEMBL1089234 — EC50 = 14000.0 nM 4.85
CHEMBL1091653 — EC50 = 16000.0 nM 4.80
CHEMBL1093988 — EC50 = 17000.0 nM 4.77
CHEMBL1092614 — EC50 = 17000.0 nM 4.77
CHEMBL111951 — EC50 = 19000.0 nM 4.72
CHEMBL1093874 — EC50 = 19000.0 nM 4.72
CHEMBL418899 2'-B-METHYL-GUANOSINE EC50 = 20000.0 nM 4.70
CHEMBL1095562 — EC50 = 21000.0 nM 4.68
CHEMBL1093873 — EC50 = 22000.0 nM 4.66
CHEMBL1093827 — EC50 = 24000.0 nM 4.62
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE EC50 = 27000.0 nM 4.57
CHEMBL1090678 — EC50 = 27000.0 nM 4.57
CHEMBL1092937 — EC50 = 30000.0 nM 4.52
CHEMBL1091651 — EC50 = 32000.0 nM 4.50
CHEMBL1090903 — EC50 = 32000.0 nM 4.50
CHEMBL1089235 — EC50 = 40000.0 nM 4.40
CHEMBL1089893 — EC50 = 45000.0 nM 4.35
CHEMBL341112 — EC50 = 87000.0 nM 4.06
CHEMBL1092966 — EC50 > 25000.0 nM -
CHEMBL1092095 — EC50 > 20000.0 nM -
CHEMBL1092674 — EC50 > 80000.0 nM -
CHEMBL1092746 — EC50 > 18000.0 nM -
CHEMBL1092967 — EC50 > 100000.0 nM -
CHEMBL1092984 — EC50 > 100000.0 nM -
CHEMBL1092935 — EC50 > 75000.0 nM -
CHEMBL1092936 — EC50 > 100000.0 nM -