Assay Detail
Binding
CHEMBL1107235
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Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 7.59 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093897 | — | — | 1 | 8.72 |
| CHEMBL1089454 | — | — | 1 | 8.55 |
| CHEMBL1090458 | — | — | 1 | 8.49 |
| CHEMBL1091164 | — | — | 1 | 8.48 |
| CHEMBL1090113 | — | — | 1 | 8.48 |
| CHEMBL1093797 | — | — | 1 | 8.48 |
| CHEMBL1089455 | — | — | 1 | 8.39 |
| CHEMBL1089491 | — | — | 1 | 8.37 |
| CHEMBL1090112 | — | — | 1 | 8.36 |
| CHEMBL1090222 | — | — | 1 | 8.35 |
| CHEMBL1093843 | — | — | 1 | 8.30 |
| CHEMBL1088823 | — | — | 1 | 8.28 |
| CHEMBL1090460 | — | — | 1 | 8.27 |
| CHEMBL1088785 | — | — | 1 | 8.27 |
| CHEMBL1089094 | — | — | 1 | 8.26 |
| CHEMBL1090501 | — | — | 1 | 8.25 |
| CHEMBL1088780 | — | — | 1 | 8.19 |
| CHEMBL1089161 | — | — | 1 | 8.17 |
| CHEMBL1088822 | — | — | 1 | 8.16 |
| CHEMBL1093792 | — | — | 1 | 8.12 |
| CHEMBL1089095 | — | — | 1 | 8.11 |
| CHEMBL1088846 | — | — | 1 | 8.09 |
| CHEMBL1092230 | — | — | 1 | 8.03 |
| CHEMBL1093559 | — | — | 1 | 8.03 |
| CHEMBL1093125 | — | — | 1 | 8.03 |
| CHEMBL1090507 | — | — | 1 | 8.01 |
| CHEMBL1088815 | — | — | 1 | 7.99 |
| CHEMBL479868 | — | — | 1 | 7.97 |
| CHEMBL1093133 | — | — | 1 | 7.90 |
| CHEMBL1090454 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093897 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1089454 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1090458 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1091164 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1090113 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1093797 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1089455 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1089491 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1090112 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1090222 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1093843 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1088823 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1090460 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1088785 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1089094 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1090501 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1088780 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL1089161 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1088822 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1093792 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1089095 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL1088846 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL1092230 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1093559 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1093125 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1090507 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1088815 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL479868 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL1093133 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL1090454 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1093790 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL1093791 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL1090459 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1093240 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL1089807 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL1090888 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL1090455 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL1088848 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL1090498 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1091145 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1088847 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL1092871 | — | IC50 | = | 55.4 | nM | 7.26 |
| CHEMBL1091146 | — | IC50 | = | 55.4 | nM | 7.26 |
| CHEMBL1093239 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL1090499 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1091165 | — | IC50 | = | 82.4 | nM | 7.08 |
| CHEMBL1091893 | — | IC50 | = | 92.8 | nM | 7.03 |
| CHEMBL1093124 | — | IC50 | = | 95.8 | nM | 7.02 |
| CHEMBL1090342 | — | IC50 | = | 96.5 | nM | 7.01 |
| CHEMBL1090889 | — | IC50 | = | 125.1 | nM | 6.90 |