Assay Detail
Binding
CHEMBL1107243
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Binding affinity to human EP4 receptor by radioligand displacement assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.17 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093792 | — | — | 1 | 5.64 |
| CHEMBL1093125 | — | — | 1 | 5.06 |
| CHEMBL1093791 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093792 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1093125 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1093791 | — | IC50 | = | 15100.0 | nM | 4.82 |