Assay Detail
Functional
CHEMBL1107380
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Growth inhibition of human HT-29 cells after 72 hrs by cell titer glo assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.79 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097216 | — | — | 1 | 5.80 |
| CHEMBL1099246 | — | — | 1 | 5.80 |
| CHEMBL1097218 | — | — | 1 | 5.39 |
| CHEMBL1099245 | — | — | 1 | 4.70 |
| CHEMBL1098905 | — | — | 1 | 4.68 |
| CHEMBL1097215 | — | — | 1 | 4.65 |
| CHEMBL1099244 | — | — | 1 | 4.62 |
| CHEMBL1097587 | — | — | 1 | 4.59 |
| CHEMBL1095631 | — | — | 1 | 4.58 |
| CHEMBL1097586 | — | — | 1 | 4.57 |
| CHEMBL1094589 | — | — | 1 | 4.50 |
| CHEMBL1098959 | — | — | 1 | 4.32 |
| CHEMBL1098960 | — | — | 1 | 4.11 |
| CHEMBL1094262 | — | — | 1 | - |
| CHEMBL1095921 | — | — | 1 | - |
| CHEMBL1094591 | — | — | 1 | - |
| CHEMBL1097923 | — | — | 1 | - |
| CHEMBL1097922 | — | — | 1 | - |
| CHEMBL1097921 | — | — | 1 | - |
| CHEMBL1096598 | — | — | 1 | - |
| CHEMBL1094590 | — | — | 1 | - |
| CHEMBL1094588 | — | — | 1 | - |
| CHEMBL1094268 | — | — | 1 | - |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | - |
| CHEMBL1097584 | — | — | 1 | - |
| CHEMBL1097585 | — | — | 1 | - |
| CHEMBL1097217 | — | — | 1 | - |
| CHEMBL1095632 | — | — | 1 | - |
| CHEMBL1099243 | — | — | 1 | - |
| CHEMBL1095583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097216 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1099246 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1097218 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1099245 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1098905 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1097215 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1099244 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1097587 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1095631 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1097586 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1094589 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1098959 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1098960 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL1094263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094262 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095921 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094591 | — | IC50 | - | — | - | |
| CHEMBL1097923 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097922 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097921 | — | IC50 | - | — | - | |
| CHEMBL1096598 | — | IC50 | - | — | - | |
| CHEMBL1094590 | — | IC50 | - | — | - | |
| CHEMBL1094588 | — | IC50 | - | — | - | |
| CHEMBL1094268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL779 | TADALAFIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097584 | — | IC50 | - | — | - | |
| CHEMBL1097585 | — | IC50 | - | — | - | |
| CHEMBL1097217 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095632 | — | IC50 | - | — | - | |
| CHEMBL1099243 | — | IC50 | - | — | - | |
| CHEMBL1095583 | — | IC50 | > | 100000.0 | nM | - |