Assay Detail
Binding
CHEMBL1107382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.40 |
| CHEMBL1099245 | — | — | 1 | 7.42 |
| CHEMBL1094263 | — | — | 1 | 7.40 |
| CHEMBL1094590 | — | — | 1 | 7.30 |
| CHEMBL1097923 | — | — | 1 | 7.30 |
| CHEMBL1097587 | — | — | 1 | 7.22 |
| CHEMBL1097584 | — | — | 1 | 7.00 |
| CHEMBL1096598 | — | — | 1 | 6.58 |
| CHEMBL1098905 | — | — | 1 | 6.54 |
| CHEMBL1094268 | — | — | 1 | 6.50 |
| CHEMBL1099244 | — | — | 1 | 6.19 |
| CHEMBL1097586 | — | — | 1 | 5.55 |
| CHEMBL1095632 | — | — | 1 | 5.51 |
| CHEMBL1094591 | — | — | 1 | 5.47 |
| CHEMBL1099243 | — | — | 1 | 5.40 |
| CHEMBL1098959 | — | — | 1 | 5.25 |
| CHEMBL1097215 | — | — | 1 | 5.21 |
| CHEMBL1097216 | — | — | 1 | 4.54 |
| CHEMBL1094589 | — | — | 1 | 4.50 |
| CHEMBL1094588 | — | — | 1 | 4.39 |
| CHEMBL1095583 | — | — | 1 | 4.13 |
| CHEMBL1097585 | — | — | 1 | 4.06 |
| CHEMBL1099246 | — | — | 1 | - |
| CHEMBL1097921 | — | — | 1 | - |
| CHEMBL1097922 | — | — | 1 | - |
| CHEMBL1097218 | — | — | 1 | - |
| CHEMBL1097217 | — | — | 1 | - |
| CHEMBL1095921 | — | — | 1 | - |
| CHEMBL1094262 | — | — | 1 | - |
| CHEMBL1095631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1099245 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1094263 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1094590 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1097923 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1097587 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1097584 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1096598 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1098905 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1094268 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1099244 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1097586 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1095632 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1094591 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1099243 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1098959 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1097215 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1097216 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1094589 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1094588 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1095583 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL1097585 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL1099246 | — | IC50 | - | — | - | |
| CHEMBL1097921 | — | IC50 | - | — | - | |
| CHEMBL1097922 | — | IC50 | - | — | - | |
| CHEMBL1097218 | — | IC50 | - | — | - | |
| CHEMBL1097217 | — | IC50 | - | — | - | |
| CHEMBL1095921 | — | IC50 | - | — | - | |
| CHEMBL1094262 | — | IC50 | - | — | - | |
| CHEMBL1095631 | — | IC50 | - | — | - | |
| CHEMBL1098960 | — | IC50 | - | — | - |