Assay Detail
Functional
CHEMBL1107398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins by rapid filtration assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Uracil nucleotide/cysteinyl leukotriene receptor (CHEMBL1075162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.16 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097279 | CANGRELOR TETRASODIUM | 4.0 | 1 | 9.15 |
| CHEMBL1094109 | — | — | 1 | 6.95 |
| CHEMBL1096400 | — | — | 1 | 6.29 |
| CHEMBL1094760 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097279 | CANGRELOR TETRASODIUM | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1094109 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1096400 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL1094760 | — | IC50 | = | 582.0 | nM | 6.24 |