Assay Detail
Binding
CHEMBL1107753
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Inhibition of GST-tagged JAK2 kinase
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078889 | — | — | 1 | 8.70 |
| CHEMBL1078274 | — | — | 1 | 8.52 |
| CHEMBL1079077 | — | — | 1 | 8.40 |
| CHEMBL1079078 | — | — | 1 | 8.22 |
| CHEMBL1078275 | — | — | 1 | 8.22 |
| CHEMBL1078005 | — | — | 1 | 8.10 |
| CHEMBL1078277 | — | — | 1 | 8.10 |
| CHEMBL1078689 | — | — | 1 | 8.05 |
| CHEMBL1078166 | — | — | 1 | 8.00 |
| CHEMBL1078276 | — | — | 1 | 7.96 |
| CHEMBL1078688 | — | — | 1 | 7.92 |
| CHEMBL1078866 | — | — | 1 | 7.85 |
| CHEMBL1080411 | — | — | 1 | 7.80 |
| CHEMBL1078767 | — | — | 1 | 7.80 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 7.75 |
| CHEMBL1078971 | — | — | 1 | 7.75 |
| CHEMBL1078364 | — | — | 1 | 7.52 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.48 |
| CHEMBL1081138 | — | — | 1 | 7.48 |
| CHEMBL1078934 | — | — | 1 | 7.39 |
| CHEMBL1078933 | — | — | 1 | 7.33 |
| CHEMBL1077842 | — | — | 1 | 7.28 |
| CHEMBL1078363 | — | — | 1 | 7.19 |
| CHEMBL1077458 | — | — | 1 | 7.17 |
| CHEMBL1077841 | — | — | 1 | 7.16 |
| CHEMBL1080955 | — | — | 1 | 7.09 |
| CHEMBL1080954 | — | — | 1 | 7.08 |
| CHEMBL1077431 | — | — | 1 | 7.06 |
| CHEMBL1078229 | — | — | 1 | 6.95 |
| CHEMBL1078228 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078889 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1078274 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1079077 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1079078 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1078275 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1078005 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1078277 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1078689 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1078166 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1078276 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1078688 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1078866 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1080411 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1078767 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1078971 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1078364 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1081138 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1078934 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1078933 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1077842 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1078363 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1077458 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1077841 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1080955 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1080954 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1077431 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1078229 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1078228 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1078165 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1078721 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL1078720 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL1079120 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL1079690 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1078370 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL1077575 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL1080395 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL1079689 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL1079121 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1080394 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL1078984 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL1078453 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL1078159 | — | IC50 | = | 545.0 | nM | 6.26 |