Assay Detail
Binding
CHEMBL1107779
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Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.83 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077284 | — | — | 1 | 5.14 |
| CHEMBL1093743 | — | — | 1 | 4.82 |
| CHEMBL1093740 | — | — | 1 | 4.68 |
| CHEMBL1093386 | — | — | 1 | 4.67 |
| CHEMBL1093739 | — | — | 1 | - |
| CHEMBL1093741 | — | — | 1 | - |
| CHEMBL1093742 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077284 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1093743 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1093740 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL1093386 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL1093739 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1093741 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1093742 | — | IC50 | > | 30000.0 | nM | - |