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Assay Detail

CHEMBL1107839

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HOP
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-5/beta-1 (CHEMBL2095226)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
Rerat V, Laurent S, Burtéa C, Driesschaert B, Pourcelle V, Vander Elst L, Muller RN, Marchand-Brynaert J.
Bioorg Med Chem Lett (2010) 20 : 1861 -1865
PubMed 20172716 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 9.56 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL565693 1 10.00
CHEMBL1077192 1 9.52
CHEMBL1077191 1 9.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL565693 IC50 = 0.1 nM 10.00
CHEMBL1077192 IC50 = 0.3 nM 9.52
CHEMBL1077191 IC50 = 0.7 nM 9.15