Assay Detail
Binding
CHEMBL1107850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST tagged JAK2 after 60 mins by Caliper mobility shift assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of two new chemotypes for inhibiting the Janus kinase 2 by scaffold morphing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.81 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205098 | — | — | 1 | 8.23 |
| CHEMBL1081290 | — | — | 1 | 7.82 |
| CHEMBL1093749 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205098 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1081290 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1093749 | — | IC50 | = | 42.0 | nM | 7.38 |