Assay Detail
Binding
CHEMBL1107897
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Inhibition of mTOR
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.46 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090381 | — | — | 1 | 9.42 |
| CHEMBL1092781 | — | — | 1 | 9.41 |
| CHEMBL1091456 | — | — | 1 | 9.34 |
| CHEMBL1091492 | — | — | 1 | 9.30 |
| CHEMBL1092815 | — | — | 1 | 9.26 |
| CHEMBL1092120 | — | — | 1 | 9.25 |
| CHEMBL1091491 | — | — | 1 | 9.17 |
| CHEMBL1094015 | — | — | 1 | 9.14 |
| CHEMBL1094017 | — | — | 1 | 9.03 |
| CHEMBL1092485 | — | — | 1 | 9.00 |
| CHEMBL1092119 | — | — | 1 | 8.85 |
| CHEMBL1093754 | — | — | 1 | 8.73 |
| CHEMBL1090388 | — | — | 1 | 8.70 |
| CHEMBL1090382 | — | — | 1 | 8.68 |
| CHEMBL1092768 | — | — | 1 | 8.66 |
| CHEMBL1090383 | — | — | 1 | 8.56 |
| CHEMBL1092486 | — | — | 1 | 8.51 |
| CHEMBL1090043 | — | — | 1 | 8.46 |
| CHEMBL1088745 | — | — | 1 | 8.34 |
| CHEMBL1094016 | — | — | 1 | 7.77 |
| CHEMBL1088746 | — | — | 1 | 7.75 |
| CHEMBL1092474 | — | — | 1 | 7.72 |
| CHEMBL1092814 | — | — | 1 | 7.72 |
| CHEMBL1091071 | — | — | 1 | 7.48 |
| CHEMBL1091455 | — | — | 1 | 7.38 |
| CHEMBL1092818 | — | — | 1 | 6.75 |
| CHEMBL1091070 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090381 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1092781 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL1091456 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL1091492 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1092815 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL1092120 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1091491 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1094015 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL1094017 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL1092485 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1092119 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1093754 | — | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL1090388 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1090382 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1092768 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1090383 | — | IC50 | = | 2.75 | nM | 8.56 |
| CHEMBL1092486 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1090043 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL1088745 | — | IC50 | = | 4.55 | nM | 8.34 |
| CHEMBL1094016 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1088746 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1092474 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1092814 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1091071 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1091455 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1092818 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1091070 | — | IC50 | = | 800.0 | nM | 6.10 |