Assay Detail
Functional
CHEMBL1108118
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Antagonist activity at human S1P1 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP binding after 30 mins by scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.46 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475405 | — | — | 1 | 9.28 |
| CHEMBL1093429 | — | — | 1 | 8.84 |
| CHEMBL1093823 | — | — | 1 | 8.79 |
| CHEMBL514170 | — | — | 1 | 8.66 |
| CHEMBL225155 | — | — | 1 | 8.25 |
| CHEMBL1090796 | — | — | 1 | 7.74 |
| CHEMBL1090829 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475405 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL1093429 | — | EC50 | = | 1.44 | nM | 8.84 |
| CHEMBL1093823 | — | EC50 | = | 1.62 | nM | 8.79 |
| CHEMBL514170 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL225155 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1090796 | — | EC50 | = | 18.3 | nM | 7.74 |
| CHEMBL1090829 | — | EC50 | = | 22.4 | nM | 7.65 |