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Assay Detail

CHEMBL1108201

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Clostridium perfringens neuraminidase assessed as inhibition of 4-MU-NANA hydrolysis after 10 mins by spectrofluorimetry
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Clostridium perfringens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sialidase (CHEMBL5189)
Type SINGLE PROTEIN
Organism Clostridium perfringens

Publication

Prenylated pterocarpans as bacterial neuraminidase inhibitors.
Nguyen PH, Nguyen TN, Kang KW, Ndinteh DT, Mbafor JT, Kim YR, Oh WK.
Bioorg Med Chem (2010) 18 : 3335 -3344
PubMed 20363636 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.22 5.89
Activity 16 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1086764 ERYSUBIN E 2 5.89
CHEMBL1096406 ERYTHRIBYSSIN O 2 5.88
CHEMBL1096407 CALOPOCARPIN 2 5.80
CHEMBL1088321 SOPHORAPTEROCARPAN A 2 5.70
CHEMBL1088462 ERYSTAGALLIN A 2 5.69
CHEMBL1097045 ERYVARIN D 2 5.68
CHEMBL454849 ERYTHRABYSSIN I 2 5.64
CHEMBL1096408 ERYTHRIBYSSIN L 2 5.55
CHEMBL1098413 DEMETHYLMEDICARPIN 2 5.19
CHEMBL1098729 ISONEORAUTENOL 2 4.85
CHEMBL1098728 NEORAUTENOL 2 4.70
CHEMBL50 QUERCETIN 3.0 2 4.60
CHEMBL1095422 ERYSUBIN D 2 4.58
CHEMBL448350 PHASEOLIN 2 4.47
CHEMBL1099089 ERYTHRIBYSSIN D 2 4.11
CHEMBL1099090 ERYTHRIBYSSIN M 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1086764 ERYSUBIN E IC50 = 1300.0 nM 5.89
CHEMBL1096406 ERYTHRIBYSSIN O IC50 = 1320.0 nM 5.88
CHEMBL1096407 CALOPOCARPIN IC50 = 1570.0 nM 5.80
CHEMBL1088321 SOPHORAPTEROCARPAN A IC50 = 2010.0 nM 5.70
CHEMBL1088462 ERYSTAGALLIN A IC50 = 2040.0 nM 5.69
CHEMBL1097045 ERYVARIN D IC50 = 2090.0 nM 5.68
CHEMBL454849 ERYTHRABYSSIN I IC50 = 2280.0 nM 5.64
CHEMBL1096408 ERYTHRIBYSSIN L IC50 = 2790.0 nM 5.55
CHEMBL1098413 DEMETHYLMEDICARPIN IC50 = 6390.0 nM 5.19
CHEMBL1098729 ISONEORAUTENOL IC50 = 14120.0 nM 4.85
CHEMBL1098728 NEORAUTENOL IC50 = 19820.0 nM 4.70
CHEMBL50 QUERCETIN IC50 = 25340.0 nM 4.60
CHEMBL1095422 ERYSUBIN D IC50 = 26390.0 nM 4.58
CHEMBL448350 PHASEOLIN IC50 = 33550.0 nM 4.47
CHEMBL1099089 ERYTHRIBYSSIN D IC50 = 77100.0 nM 4.11
CHEMBL1099090 ERYTHRIBYSSIN M IC50 = 205400.0 nM -
CHEMBL1098413 DEMETHYLMEDICARPIN Activity - -
CHEMBL1098728 NEORAUTENOL Activity - -
CHEMBL1098729 ISONEORAUTENOL Activity - -
CHEMBL448350 PHASEOLIN Activity - -
CHEMBL1097045 ERYVARIN D Activity - -
CHEMBL1096406 ERYTHRIBYSSIN O Activity - -
CHEMBL1096407 CALOPOCARPIN Activity - -
CHEMBL1096408 ERYTHRIBYSSIN L Activity - -
CHEMBL1095422 ERYSUBIN D Activity - -
CHEMBL1086764 ERYSUBIN E Activity - -
CHEMBL1099089 ERYTHRIBYSSIN D Activity - -
CHEMBL1099090 ERYTHRIBYSSIN M Activity - -
CHEMBL454849 ERYTHRABYSSIN I Activity - -
CHEMBL1088321 SOPHORAPTEROCARPAN A Activity - -
CHEMBL1088462 ERYSTAGALLIN A Activity - -
CHEMBL50 QUERCETIN Activity - -