Assay Detail
Functional
CHEMBL1108345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 69 | 6.81 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095833 | — | — | 1 | 8.04 |
| CHEMBL1096146 | PONESIMOD | 4.0 | 1 | 8.01 |
| CHEMBL1094503 | — | — | 1 | 8.00 |
| CHEMBL1096873 | — | — | 1 | 7.96 |
| CHEMBL1097184 | — | — | 1 | 7.92 |
| CHEMBL1096872 | — | — | 1 | 7.72 |
| CHEMBL1097809 | — | — | 1 | 7.51 |
| CHEMBL1095152 | — | — | 1 | 7.47 |
| CHEMBL1097808 | — | — | 1 | 7.46 |
| CHEMBL1095995 | — | — | 1 | 7.43 |
| CHEMBL1098143 | — | — | 1 | 7.33 |
| CHEMBL1094192 | — | — | 1 | 7.33 |
| CHEMBL1097807 | — | — | 1 | 7.27 |
| CHEMBL1094831 | — | — | 1 | 7.26 |
| CHEMBL1094501 | — | — | 1 | 7.24 |
| CHEMBL1096676 | — | — | 1 | 7.24 |
| CHEMBL1096786 | — | — | 1 | 7.21 |
| CHEMBL1097103 | — | — | 1 | 7.17 |
| CHEMBL1097535 | — | — | 1 | 7.14 |
| CHEMBL1098142 | — | — | 1 | 7.11 |
| CHEMBL1097801 | — | — | 1 | 7.02 |
| CHEMBL1097800 | — | — | 1 | 7.01 |
| CHEMBL1098449 | — | — | 1 | 6.99 |
| CHEMBL1097843 | — | — | 1 | 6.99 |
| CHEMBL1098447 | — | — | 1 | 6.99 |
| CHEMBL1098144 | — | — | 1 | 6.97 |
| CHEMBL1095153 | — | — | 1 | 6.96 |
| CHEMBL1094213 | — | — | 1 | 6.95 |
| CHEMBL1098811 | — | — | 1 | 6.91 |
| CHEMBL1097537 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095833 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL1096146 | PONESIMOD | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL1094503 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1096873 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1097184 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1096872 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1097809 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1095152 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1097808 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1095995 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1098143 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1094192 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1097807 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1094831 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1096676 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1094501 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1096786 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1097103 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1097535 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1098142 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1097801 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1097800 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1098449 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1097843 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1098447 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1098144 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1095153 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1094213 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1098811 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL1097537 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL1097182 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1098203 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1098448 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL1098467 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1097536 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL1096788 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL1098770 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL1098450 | — | EC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1098200 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1098201 | — | EC50 | = | 201.0 | nM | 6.70 |
| CHEMBL1098013 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1098202 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL1094885 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1096478 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL1094699 | — | EC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1094502 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1097803 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL1094834 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL1094247 | — | EC50 | = | 356.0 | nM | 6.45 |
| CHEMBL1097529 | — | EC50 | = | 408.0 | nM | 6.39 |