Assay Detail
Functional
CHEMBL1108592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, characterization and structure-activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.58 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088434 | — | — | 1 | 5.40 |
| CHEMBL1087764 | — | — | 1 | 4.82 |
| CHEMBL1088294 | — | — | 1 | 4.57 |
| CHEMBL1087390 | — | — | 1 | 4.52 |
| CHEMBL1088433 | — | — | 1 | 4.46 |
| CHEMBL1087765 | — | — | 1 | 4.46 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.30 |
| CHEMBL98369 | — | — | 1 | 4.10 |
| CHEMBL1076756 | — | — | 1 | - |
| CHEMBL1076801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088434 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1087764 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1088294 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1087390 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1088433 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1087765 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL852 | MELPHALAN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL98369 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1076756 | — | IC50 | - | — | - | |
| CHEMBL1076801 | — | IC50 | - | — | - |