Assay Detail
Binding
CHEMBL1108763
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Displacement of [125I]MCP1 from human CCR2B receptor expressed in HEK293-EBNA cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.69 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092929 | — | — | 1 | 6.24 |
| CHEMBL337246 | — | — | 1 | 6.21 |
| CHEMBL1093469 | — | — | 1 | 6.00 |
| CHEMBL1089965 | — | — | 1 | 6.00 |
| CHEMBL1092238 | — | — | 1 | 5.95 |
| CHEMBL1089881 | — | — | 1 | 5.95 |
| CHEMBL1090548 | — | — | 1 | 5.93 |
| CHEMBL495202 | — | — | 1 | 5.92 |
| CHEMBL1088874 | — | — | 1 | 5.88 |
| CHEMBL1092921 | — | — | 1 | 5.85 |
| CHEMBL1092293 | — | — | 1 | 5.76 |
| CHEMBL1092294 | — | — | 1 | 5.76 |
| CHEMBL1093802 | — | — | 1 | 5.73 |
| CHEMBL1089629 | — | — | 1 | 5.66 |
| CHEMBL1090206 | — | — | 1 | 5.54 |
| CHEMBL1089793 | — | — | 1 | 5.52 |
| CHEMBL1088875 | — | — | 1 | 5.50 |
| CHEMBL255408 | — | — | 1 | 5.50 |
| CHEMBL1093153 | — | — | 1 | 5.46 |
| CHEMBL1092343 | — | — | 1 | 5.45 |
| CHEMBL1093470 | — | — | 1 | 5.35 |
| CHEMBL1092920 | — | — | 1 | 5.18 |
| CHEMBL1089849 | — | — | 1 | 5.12 |
| CHEMBL1092656 | — | — | 1 | 5.08 |
| CHEMBL254355 | — | — | 1 | - |
| CHEMBL1093154 | — | — | 1 | - |
| CHEMBL273083 | — | — | 1 | - |
| CHEMBL1088810 | — | — | 1 | - |
| CHEMBL1090148 | — | — | 1 | - |
| CHEMBL1091171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092929 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL337246 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1093469 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1089965 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1092238 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1089881 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1090548 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL495202 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1088874 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL1092921 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1092293 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL1092294 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1093802 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL1089629 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL1090206 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1089793 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL1088875 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL255408 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1093153 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL1092343 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL1093470 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1092920 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1089849 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL1092656 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL254355 | — | IC50 | = | 2400.0 | nM | - |
| CHEMBL1093154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL273083 | — | IC50 | = | 5100.0 | nM | - |
| CHEMBL1088810 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1090148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091171 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091172 | — | IC50 | > | 10000.0 | nM | - |