Assay Detail
Binding
CHEMBL1108781
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Inhibition of dopamine D4 (receptor)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.42 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093802 | — | — | 1 | 5.42 |
| CHEMBL1092929 | — | — | 1 | - |
| CHEMBL1089881 | — | — | 1 | - |
| CHEMBL1092921 | — | — | 1 | - |
| CHEMBL1088874 | — | — | 1 | - |
| CHEMBL1093469 | — | — | 1 | - |
| CHEMBL1092238 | — | — | 1 | - |
| CHEMBL1089793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093802 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1092929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1089881 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1092921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1088874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1093469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1092238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1089793 | — | IC50 | > | 10000.0 | nM | - |